Gene editing in veterinary pathophysiology
نویسندگان
چکیده
منابع مشابه
Lactate in veterinary critical care: pathophysiology and management.
The measurement of blood lactate in people has proven to be a useful tool in the diagnosis, monitoring, and prognosis of a wide range of clinical syndromes. Its use in small animals is increasing, and several studies have been completed that demonstrate its potential role in critical care. This article summarizes the current state of knowledge regarding the physiology and pathophysiology of lac...
متن کاملGene Editing Versus Morphants
Kok et al. conclude that results with Morpholino oligos, which are not recapitulated by natural mutations or gene editing mutations, must be due to off-target effects and, when morphants and mutants differ, they contend that antisense oligo studies should be disregarded. Morpholinos and gene editing mutagenesis are very different technologies and, even if both work perfectly, may yield differen...
متن کاملCorrigendum: Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy
This corrects the article DOI: 10.1038/ncomms14454.
متن کاملMuscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy
Gene replacement therapies utilizing adeno-associated viral (AAV) vectors hold great promise for treating Duchenne muscular dystrophy (DMD). A related approach uses AAV vectors to edit specific regions of the DMD gene using CRISPR/Cas9. Here we develop multiple approaches for editing the mutation in dystrophic mdx4cv mice using single and dual AAV vector delivery of a muscle-specific Cas9 casse...
متن کاملEthics and germline gene editing.
T he current kerfuffle around the use of CRISPR/Cas9 and other gene editing technologies in human germline research is the latest in a series of related controversies at the intersection of science, medicine, and ethics [1]. Soon after a prominent ad hoc group of scientists called for a moratorium on clinical applications of germline gene editing [2], a research group from China published an ar...
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ژورنال
عنوان ژورنال: Veterinary Quarterly
سال: 2016
ISSN: 0165-2176,1875-5941
DOI: 10.1080/01652176.2016.1139899